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In addition to hunting, the three major determinants of moose survival are predators, snow conditions and disease.

The timber wolf is the most serious predator of moose in Alaska. They often detect moose by scent. When the moose population is thriving, wolves act as a culling agent for old or diseased animals and weakened calves. When the moose becomes aware of danger, it can either stand and fight or run. A single wolf or a small group of wolves are no match for a healthy moose, which uses all four powerful legs to strike an opponent. However, a group of more than four or five wolves can pull down and kill a large moose. If the moose decides to run, wolves give chase and attempt to slow the moose by grabbing it by the nose, rump, or hocks. In this case, an organized attack by a large group of hungry wolves is often fatal for the moose.

In the Yukon and Alaska, calf predation by grizzly and black bears has been shown to have a major effect on the size of moose populations. This may also be the case in Alaska, but to date no data are available.

Predation and snow conditions are interrelated factors that can have a significant effect on moose numbers. When snow is deep and moose ''yard'' together, they are more accessible in greater numbers to wolves. Moose have relatively long legs that allow them travel through deep snow easier than most other ungulates. However, snow depth of over 90 cm greatly hinders their movements and their foraging ability is seriously restricted. Crusted snow can also be detrimental to moose in that it can pierce the skin on the forelegs and crack the hooves, making it vulnerable to predation.

Moose are susceptible to a variety of parasites.

 

Tapeworms that cause cysts do not directly influence moose mortality, but instead hinder their response to stress. Three types of tapeworms that can be found in moose in Alaska are liver tapeworm cysts (Taenia hydatigena), hydatid disease in the lungs (Echinococcus granulosus), and muscle tapeworm cysts (Taenia krabbei).

 

"Moose disease" is caused by a parasitic roundworm (P. tenuis) carried and transmitted by white-tailed deer. Infestation in moose can damage the central nervous system and ultimately invade the brain, usually causing death. The symptoms of the disease include walking in circles, bumping into objects, losing fear of man, and general lack of co-ordination. "Moose disease" is not found in Alaska and Western Canada at this time.

 

Ticks (Demacentor albipictus) feed on the blood of the moose, severely weakening the animals and causing hair loss which then increases heat loss.

In some places a significant number of moose are killed through collisions with motor vehicles. This has a significant impact on the moose population each year in Alaska because of moose accidents with motor vehicles. Other minor causes of mortality to moose are drowning, falls, and wounds caused during rutting combat.

 

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